CAS NO.1119275-41-0 4′-(trans-4-Butylcyclohexyl)-4-[difluoro(3,4,5-trifluorophenoxy)methyl]-3,5-difluoro-1,1′-biphenyl

Frequently Asked Questions：

Q1: What is the CAS number and molecular formula of this product?

The CAS Registry Number is 1119275-41-0. The molecular formula is C₂₉H₂₇F₇O with a molecular weight of 524.51 g/mol. It belongs to the class of fluorinated biphenyl liquid crystal intermediates.

Q2: What are the physical properties of this compound?

The compound appears as a white to off-white solid. The predicted boiling point is 524.594±50.00 °C (at 760 Torr) and the predicted density is 1.237±0.06 g/cm³ at 25 °C. Standard purity is ≥98% by GC, with ≥99% available upon request.

Q3: What are the main applications of CAS 1119275-41-0?

This compound is primarily used as:
• A key organic synthetic intermediate for advanced nematic liquid crystal mixtures in TFT-LCD and IPS/FFS display panels;
• A building block for OLED and organic semiconductor materials;
• A synthetic intermediate in fluorinated pharmaceutical and agrochemical R&D.

Q4: How should this product be stored?

Store in a well-closed container in a cool, dry place, protected from light. Recommended storage temperature is 2–8 °C. Under proper conditions, the shelf life exceeds 24 months.

Q5: What packaging options are available?

Standard packaging includes fluoride bottles, HDPE drums, iron drums, plastic drums, or IBC tanks. Custom packaging specifications can be accommodated upon request. Small quantities (1 g–100 g) are available in amber glass bottles with PTFE-lined caps.

Application Cases：

Case 1: High-Performance TFT-LCD for Automotive Displays

Challenge: An automotive display manufacturer needed to develop a liquid crystal mixture that maintains stable performance across a wide temperature range (−40 °C to +105 °C) while achieving fast response times for in-vehicle infotainment systems.

Solution: CAS 1119275-41-0 was incorporated at 5–12 wt% into a multi-component nematic LC host mixture. Its trans-bicyclohexyl core provided high clearing point (> 130 °C), while the heavily fluorinated terminal group lowered rotational viscosity and improved low-temperature fluidity.

Result: The optimized mixture achieved a response time of < 8 ms at −30 °C and maintained VHR > 95% after 500 hours of UV aging, meeting automotive-grade reliability standards (AEC-Q100 equivalent).

Case 2: IPS/FFS Display Panel for High-End Smartphones

Challenge: A display panel maker sought to improve the viewing angle contrast ratio and reduce power consumption in their flagship IPS smartphone panel without sacrificing response speed.

Solution: This fluorinated biphenyl compound was added at 8 wt% to the LC formulation. Its high birefringence (Δn ≈ 0.12–0.14) allowed for a thinner cell gap (from 3.8 μm to 3.3 μm), while the low viscosity component reduced driving voltage by ~15%.

Result: The panel achieved a contrast ratio improvement of 20% at 80° off-axis viewing, and power consumption dropped by approximately 12% due to the reduced cell gap and lower operating voltage.

Case 3: OLED Electron-Transport Layer Material Precursor

Challenge: An OLED materials company was developing a new n-type (electron-transporting) host material requiring high electron affinity and good film-forming properties for green phosphorescent OLEDs.

Solution: The trifluorophenoxy-terminated biphenyl structure of CAS 1119275-41-0 was used as a key intermediate in synthesizing a fluorinated oxadiazole derivative. The electron-withdrawing fluorine groups enhanced the LUMO energy level alignment with the cathode.

Result: The resulting OLED device showed an external quantum efficiency (EQE) of 18.2% and an operational half-lifetime (LT₉₅) exceeding 10,000 hours at 1,000 cd/m², representing a 25% improvement over the previous non-fluorinated analogue.

Case 4: Fluorinated Specialty Coating for Optical Components

Challenge: A precision optics manufacturer needed a surface coating for AR (anti-reflective) lens elements that would provide hydrophobic, anti-smudge properties while maintaining optical transparency and adhesion to glass substrates.

Solution: CAS 1119275-41-0 was functionalized via a silane coupling reaction to produce a fluorinated organosilane coating agent. The polyfluoro biphenyl core provided ultra-low surface energy, while the silane anchor ensured strong bonding to SiO₂-based AR coatings.

Result: The treated lenses exhibited a water contact angle of > 115°, oil contact angle of > 70°, and passed 1,000 cycles of abrasion testing (Taber abrasion) without significant degradation of hydrophobicity, meeting consumer electronics durability specifications.

Case 5: Fluorinated Pharmaceutical Intermediate for Kinase Inhibitor Optimization

Challenge: A pharmaceutical research institute was optimizing a kinase inhibitor lead compound with poor metabolic stability (t₁/₂ < 30 min in human liver microsomes) and needed to improve its pharmacokinetic profile.

Solution: The polyfluorinated biphenyl scaffold of CAS 1119275-41-0 was used as a privileged building block. The difluoromethoxy group served as a metabolically stable bioisostere for a labile methoxy group, while the fluorine substituents on the biphenyl core blocked oxidative metabolism hotspots.

Result: The optimized analog showed a 5-fold improvement in microsomal stability (t₁/₂ > 150 min), maintained the same target binding affinity (IC₅₀ < 10 nM), and demonstrated 3× higher oral bioavailability in rat PK studies.